Name und Anschrift


Hulscher Health Services

Sanne Hulscher

Bifangstrasse 14

8915 Hausen am Albis





Handelsregister- / Firmennummer: CH-

Mehrwertsteuernummer (MwSt-Nummer): CHE-454.503.480



Hulscher Health Services

Sanne Hulscher

Postkonto 89-569193-2 CHF

IBAN: CH65 0900 0000 8956 9193 2









Der Karies Prävalenz kann reduziert werden durch den Zuckerkonsum zu senken; vor allem aber durch zuckerhaltigen Zwischenmahlzeiten zu reduzieren.


Palacios C, Rivas-Tumanyan S, Morou-Bermúdez E, Colon AM, Torres RY, Elías-Boneta AR. (2016). Association between Type, Amount, and Pattern of Carbohydrate Consumption with Dental Caries in 12-Year-Olds in Puerto Rico. Caries Res. 2016;50(6):560-570. Epub 2016 Oct 28.


Costacurta M, DiRenzo L, Sicuro L, Gratteri S, De Lorenzo A, Docimo R. (2014). Dental caries and childhood obesity: analysis of food intakes, lifestyle. Eur J Paediatr Dent. 2014 Dec;15(4):343-8.


Sheiham A, James WP. (2014). A new understanding of the relationship between sugars, dental caries and fluoride use: implications for limits on sugars consumption. Public Health Nutr. 2014 Oct;17(10):2176-84. Epub 2014 Jun 3.


Moynihan PJ, Kelly SA. (2014). Effect on caries of restricting sugars intake: systematic review to inform WHO guidelines. J Dent Res. 2014 Jan;93(1):8-18. Epub 2013 Dec 9.


Rugg-Gunn A. (2013). Dental caries: strategies to control this preventable disease. Acta Med Acad. 2013 Nov;42(2):117-30.


Evans EW, Hayes C, Palmer CA, Bermudez OI, Cohen SA, Must A. (2013). Dietary intake and severe early childhood caries in low-income, young children. J Acad Nutr Diet. 2013 Aug;113(8):1057-61. Epub 2013 May 23.


Moynihan P, Petersen PE. (2004). Diet, nutrition and the prevention of dental diseases. Public Health Nutr. 2004 Feb;7(1A):201-26.


Touger-Decker R, van Loveren C. (2003). Sugars and dental caries. Am J Clin Nutr. 2003 Oct;78(4):881S-892S.


Marshall TA, Levy SM, Broffitt B, Warren JJ, Eichenberger-Gilmore JM, Burns TL, Stumbo PJ. (2003). Dental caries and beverage consumption in young children. Pediatrics. 2003 Sep;112(3 Pt 1):e184-91.


Sheiham A. (2001). Dietary effects on dental diseases. Public Health Nutr. 2001 Apr;4(2B):569-91.


Szpunar SM, Eklund SA, Burt BA. (1995). Sugar consumption and caries risk in schoolchildren with low caries experience. Community Dent Oral Epidemiol. 1995 Jun;23(3):142-6.


Sheiham A. (1991). Why free sugars consumption should be below 15 kg per person per year in industrialised countries: the dental evidence. Br Dent J. 1991 Jul 20;171(2):63-5.


Burt BA, Eklund SA, Morgan KJ, Larkin FE, Guire KE, Brown LO, Weintraub JA. (1988). The effects of sugars intake and frequency of ingestion on dental caries increment in a three-year longitudinal study. J Dent Res. 1988 Nov;67(11):1422-9.


Rugg-Gunn AJ, Hackett AF, Appleton DR, Jenkins GN, Eastoe JE. (1984). Relationship between dietary habits and caries increment assessed over two years in 405 English adolescent school children. Arch Oral Biol. 1984;29(12):983-92.


Lilienthal B., Goldsworthy N. E., Sullivan H. R., Cameron D. A. (1953). The biology of the children of Hopewood House, Bowral, New South Wales. I. Observations on dental caries extending over five years. Med J Aust 1953;20;40(125):878–81.




Neben Karies wird auch Parodontitis von erhöhter Zuckereinnahme gefördert


Meier T, Deumelandt P, Christen O, Stangl GI, Riedel K, Langer M. (2017). Global Burden of Sugar-Related Dental Diseases in 168 Countries and Corresponding Health Care Costs. J Dent Res. 2017 Jul;96(8):845-854. Epub 2017 May 10.


Chapple IL, Bouchard P, Cagetti MG, Campus G, Carra MC, Cocco F, Nibali L, Hujoel P, Laine ML, Lingstrom P, Manton DJ, Montero E, Pitts N, Rangé H, Schlueter N, Teughels W, Twetman S, Van Loveren C, Van der Weijden F, Vieira AR, Schulte AG. (2017). Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. J Clin Periodontol. 2017 Mar;44 Suppl 18:S39-S51.


Hujoel PP, Lingström P. (2017). Nutrition, dental caries and periodontal disease: a narrative review. J Clin Periodontol. 2017 Mar;44 Suppl 18:S79-S84.


Miranda TS, Feres M, Retamal-Valdés B, Perez-Chaparro PJ, Maciel SS, Duarte PM. (2017). Influence of glycemic control on the levels of subgingival periodontal pathogens in patients with generalized chronic periodontitis and type 2 diabetes. J Appl Oral Sci. 2017 Jan-Feb;25(1):82-89.




Süssholz/Glycyrrhiza glabra/Lakritze


Effektivität gegen oralen pathogenen


Ajagannanavar. SL, Battur. H, Shamarao. S, Sivakumar. V, Patil. PU, Shanavas. P. (2014). Effect of Aqueous and Alcoholic Licorice (Glycyrrhiza Glabra) Root Extract Against Streptococcus Mutans and Lactobacillus Acidophilus in Comparison to Chlorhexidine: An In Vitro Study J Int Oral Health. 2014 Jul-Aug; 6(4): 29–34.


Sedighinia. F, Afshar. AS, Soleimanpour. S, Zarif. R, Asili. J, Ghazvini. K. (2012). Antibacterial activity of Glycyrrhiza glabra against oral pathogens: an in vitro study Avicenna J Phytomed. 2012 Summer; 2(3): 118–124.


Messier C, Epifano F, Genovese S, Grenier D. (2012). Licorice and its potential beneficial effects in common oro-dental diseases. Oral Dis. 2012 Jan;18(1):32-9. doi: 10.1111/j.1601-0825.2011.01842.x. Epub 2011 Aug 18.



Positive systemische Effekte von Süssholz bei Diabetes


Rani R, Dahiya S, Dhingra D, Dilbaghi N, Kim KH, Kumar S. (2017). Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats. Eur J Pharm Sci. 2017 Aug 30;106:220-230.


Peng F, Du Q, Peng C, Wang N, Tang H, Xie X, Shen J, Chen J. (2015). A Review: The Pharmacology of Isoliquiritigenin. Phytother Res. 2015 Jul;29(7):969-77. doi: 10.1002/ptr.5348. Epub 2015 Apr 24.


Yehuda I, Madar Z, Leikin-Frenkel A, Tamir S. (2015). Glabridin, an isoflavan from licorice root, downregulates iNOS expression and activity under high-glucose stress and inflammation. Mol Nutr Food Res. 2015 Jun;59(6):1041-52. Epub 2015 May 3.


Gaur R, Yadav KS, Verma RK, Yadav NP, Bhakuni RS. (2014). In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. Phytomedicine. 2014 Mar 15;21(4):415-22. doi: 10.1016/j.phymed.2013.10.015. Epub 2013 Nov 19.


Wu F, Jin Z, Jin J. (2013). Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. Mol Med Rep. 2013 Apr;7(4):1278-82. doi: 10.3892/mmr.2013.1330. Epub 2013 Feb 19.


Sil R, Ray D, Chakraborti AS. (2013). Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia and oxidative stress in fructose-induced metabolic syndrome-X in rat model. Indian J Exp Biol. 2013 Feb;51(2):129-38.


Park HG, Bak EJ, Woo GH, Kim JM, Quan Z, Kim JM, Yoon HK, Cheon SH, Yoon G, Yoo YJ, Na Y, Cha JH. (2012). Licochalcone E has an antidiabetic effect. J Nutr Biochem. 2012 Jul;23(7):759-67. doi: 10.1016/j.jnutbio.2011.03.021. Epub 2011 Aug 12.


Kataya HH, Hamza AA, Ramadan GA, Khasawneh MA. (2011). Effect of licorice extract on the complications of diabetes nephropathy in rats. Drug Chem Toxicol. 2011 Apr;34(2):101-8. doi: 10.3109/01480545.2010.510524.








Effektivität gegen oralen Pathogenen und Karies


Es gibt mehrere Studien, wo bei unterschiedlichen Tagesdosierungen und Kontrollintervalle, keine signifikante Resultate von Xylit angezeigt werden konnten (meistens war dabei die Tagesdosierung unter 6 Gramm). Jedoch ein negatives Effekt (Verschlimmerung der Kariesaktivität) wurde nie beobachtet. Zum Zwecken von ZALZA würde alleine dies schon ausreichen, da das Ziel ist, den Zuckerkonsum zu senken durch das Anbieten von zahnfreundlichen Alternativen. Allerdings gibt es viele Studien, welche eine zahnschützende Wirkung von Xylitol unterstützen.



Janakiram C, Deepan Kumar CV, Joseph J. (2017). Xylitol in preventing dental caries: A systematic review and meta-analyses. J Nat Sci Biol Med. 2017 Jan-Jun;8(1):16-21. doi: 10.4103/0976-9668.198344.


American Academy of Pediatric Dentistry. Council on Clinical Affairs. (2015). Policy on the Use of Xylitol. Adopted (2006). Revised (2010, 2015). Nachgeschlagen am 10.10.2017


Nayak. PA, Nayak. UA, Khandelwal. V. (2014). The effect of xylitol on dental caries and oral flora Clin Cosmet Investig Dent. 2014; 6: 89–94. Published online 2014 Nov 10.


Kovari H, Pienihäkkinen K, Alanen P. (2003). Use of xylitol chewing gum in daycare centers: a follow-up study in Savonlinna, Finland. Acta Odontol Scand. 2003 Dec;61(6):367-70.


Campus G, Cagetti MG, Sacco G, Solinas G, Mastroberardino S, Lingström P. (2009). Six months of daily high-dose xylitol in high-risk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci. Caries Res. 2009;43(6):455-61. doi: 10.1159/000264682. Epub 2009 Dec 10.



Langfristige Effektivität von Xylitol


Campus G, Cagetti MG, Sale S, Petruzzi M, Solinas G, Strohmenger L, Lingström P. (2013). Six months of high-dose xylitol in high-risk caries subjects--a 2-year randomised, clinical trial. Clin Oral Investig. 2013 Apr;17(3):785-91. doi: 10.1007/s00784-012-0774-5. Epub 2012 Jul 13.


Fraga CP, Mayer MP, Rodrigues CR. (2010). Use of chewing gum containing 15% of xylitol and reduction in mutans streptococci salivary levels. Braz Oral Res. 2010 Apr-Jun;24(2):142-6.




Xylitol bei Babies ab 9 Monate


L. Zhan, J. Cheng, P. Chang, M. Ngo, P.K. DenBesten, C.I. Hoover, J.D.B. Featherstone (2012). Effects of Xylitol Wipes on Cariogenic Bacteria and Caries in Young Children J Dent Res. 2012 Jul; 91(7 Suppl): S85–S90.


Milgrom P, Ly KA, Tut OK, Mancl L, Roberts MC, Briand K, Gancio MJ. (2009). Xylitol pediatric topical oral syrup to prevent dental caries: a double-blind randomized clinical trial of efficacy. Arch Pediatr Adolesc Med. 2009 Jul;163(7):601-7.




Kariesprävention bei Babies und Kleinkinder durch Xylit Anwendung der Mutter


Olak. J, Saag. M, Vahlberg. T, Söderling. E, Karjalainen. S. (2012). Caries prevention with xylitol lozenges in children related to maternal anxiety. A demonstration project European archives of paediatric dentistry 2012/04/01


Thorild. I, Lindau. B, Twetman. S. (2007) Caries in 4-year-old children after maternal chewing of gums containing combinations of xylitol, sorbitol, chlorhexidine and fluoride Research Gate January 2007


Isokangas P, Söderling E, Pienihäkkinen K, Alanen P. (2000). Occurrence of dental decay in children after maternal consumption of xylitol chewing gum, a follow-up from 0 to 5 years of age. J Dent Res. 2000 Nov;79(11):1885-9.








Erythrit hilft Karies vorzubeugen, durch die Anhaftung der Plaquebakterien zu erschweren.

Mäkinen KK, Saag M, Isotupa KP, Olak J, Nõmmela R, Söderling E, Mäkinen PL. (2005) Similarity of the effects of erythritol and xylitol on some risk factors of dental caries. Caries Res. 2005 May - Jun;39(3):207-15


Soderling EM, Hietala-Lenkkeri A. (2010) Xylitol and Erythritol Decrease Adherence of Polysaccharide-Producing Oral Streptococci. Curr Mikrobiol 2010 Jan;60(1):25-9.







Deutsches Institut für Ernährungsforschung (DIfE) (2016). Ist Isomaltulose gesünder als Haushaltzucker? 15. Februar 2016 Nachgeschlagen: 06.10.2017

Eskin. M, Tamir. S. (2005) Dictionary of Nutraceuticals and Functional Foods Taylor & Francis Group 2005 Pagina 315


PEAK Performance Products S.A. Isomaltulose / Palatinose Nachgeschlagen: 06.10.2017



Gehring F, Karle EJ. (1981).  Sweetening agent, Palatinit under specific consideration as to microbiological and caries-prophylactic aspects. Z Ernahrungswiss. 1981 Jun;20(2):96-106




Studien haben herausgewiesen, dass zuckerfreie Schockolade zahnfreundlich ist, auch wenn Milchpulver enthalten ist. (Die beste Effekte treten auf, wenn Xylit als Zuckeraustauschstof verwendet wird). Der Grund dafür liegt vermutlich im schützenden Effekt vom Kakao. Zuckerfreie weisse Schokolade mit zu hohem Milchpulveranteil und zu niedrigem Kakaoanteil, wird für alle Sicherheit nicht ins Sortiment von ZALZA aufgenommen.



Hegde AM, Shetty R, Sequeira AR. (2009) The Acidogenicity of Various Chocolates Available in Indian Market: A Comparative Study Int J Clin Pediatr Dent. 2009 May-Aug; 2(2): 20–24. Published online 2009 Aug 26.


Verakaki E, Duggal MS. (2003) A comparison of different kinds of European chocolates on human plaque pH. Eur J Paediatr Dent. 2003 Dec;4(4):203-10.


Ito K1, Nakamura Y, Tokunaga T, Iijima D, Fukushima K. (2003). Anti-cariogenic properties of a water-soluble extract from cacao. Biosci Biotechnol Biochem. 2003 Dec;67(12):2567-73.


Karle VE, Gehring F. (1975) Effect of sugar-exchange fructose, sorbitol and xylitol on the incidence of caries anddental plaque flora of the rat. Dtsch Zahnarztl Z. 1975 May;30(5):356-63.








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Titelbild 'Frau mit Kaugummi'

Fotograf: David Streit


Lizenz: open source



Bild: Zahn für A,B,C Kategorien

Künstler: Tooth by Magicon from the Noun Project

Lizenz: creative commons


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